061 CD101 expression defines resident memory regulatory T cells and IFN-γ−producing CD8+ resident memory T cells in human epidermis

CD101, a transmembrane glycoprotein involved in the T cell activation, has been reported as core signature of human CD8+ resident memory (TRM) cells, but not CD4+ TRM cells. However, CD101 expression examined skin Thus, was determined both epidermal and dermal cells using noninflamed skin. Inconsistent with previous report, highly expressed tended higher than CD103+ CD103− Besides CD4 CD8 majority Foxp3+ regulatory (regTRM) CD101. Moreover, CD101+ CD101− produce Tc1 cytokines such IFN-γ TNF-α Tc17 IL-17A, respectively. This behavior is identical or without CD49a expression. Collectively, defines regTRM IFN-γ−producing Considering that are approximately four times greater epidermis they express TNF-α, healthy may be equipped to evoke Tc1-type inflammation this potential inflammatory crisis balanced by CD101-expressing regTRMcells steady-state.